The consequences of Keefe D's past actions may have caught up with him in the form of a revenge attack from inmates.
He confessed to his involvement in the killing of Tupac Shakur nearly three decades ago, and now he is also battling cancer, which may be fatal, according to his own words.
Given the perils of Las Vegas prisons, James McDonald - a former Los Angeles gang enforcer and one familiar with Keefe D from their neighborhood wars - is convinced that protective custody cells are a must-have for the 60-year-old.
For McDonald, issues will arise during Keefe's trial and in case of conviction.
Keefe D, whose real name is Duane Davis, will face the justice system in Las Vegas on Thursday morning concerning allegations of murdering Tupac.
His defense attorney has expressed that he intends to plead his innocence.
McDonald, who was known as the infamous Mob James, once served as Death Row Records' security detail.
He spoke to The Sun about Keefe D's arrival in prison. In particular, he shared his understanding that the rapper would not be able to mingle with other inmates and instead would need specialized protection.
McDonald said: "As soon as he [Keefe D] touched down in a prison... you got people that were fans of Tupac, they're going to come at him, they're going to have to put him in protective custody because he ain't going to walk no mainline."
"So with him saying it (his role in Tupac's killing), and some of the guys I know from the motorcycle set, this man is telling everybody he did it. I wish I knew where he lived.
McDonald went on to say, "The people in prison is going to try to do something to him just because it was Tupac - not just you just killed a random gang member. But because it was Tupac."
"Ain't no if, ands or buts ain't, ain't nobody not going to touch him. Guaranteed he's going to have a problem."
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The outlet also recently spoke to former Southside Crip Keefe D's attorney, Ross Goodman, who confirmed that his client had indeed been fighting colon cancer as of late.
When asked further about this medical issue, Goodman noted: "I haven't seen any medical records yet, but it does appear that Keefe was dealing with the illness before giving interviews about being involved in Tupac's murder."
Before completing his memoir "Compton Street Legend" and its admissions about his role in Tupac's death, Keefe D confided to close friends that he did not expect to live much longer. This information was reported by those associated with Keefe.
